Shoppers were promised free clothes in the capital if they could be among the first 100 outside the store
Participants began queuing in Turin late last night for the 8am opening, according to local reports.
To soften the blow, the store was selling a number of items at half price this morning.
The Spanish brand has previously held the parties in Madrid, Barcelona and other Spanish cities as well as London.
It has also been held in European capitals including Berlin, Paris, Amsterdam and Lisbon.
And the party has travelled across continents to Tokyo, in Japan, and New York in the United States.
The Seminaked Party was launched in 2005 by Desigual.
In addition to dressing in just their underwear again, participants will also be required to take part in a 100-metre race.
The Seminaked Party came to London in 2011. Despite organising the event for a summer month, shoppers were still left drenched after queuing from 11pm in the rain and cold for a 9am opening.
The first 100 through the door got a free top and bottoms, but everyone else who turned up in their underwear got treated to 50 per cent off Desigual’s summer collection.
In the England capital, the half-naked shoppers were serenaded by Australian band Set SailĀ and treated to goodie bags as they queued.
-DailyMail