Two died on the spot while two others were confirmed dead later at the hospital.
Nineteen others who sustained various injuries are receiving treatment at the Our Lady of Mercy Hospital at Apam.
According to the Central Regional Public Relations Officer of the Ghana National Fire Service (GNFS), Assistant Division Officer III, Abdul Wasui Hudu the accident involved a Mecedes Benz Sprinter bus with registration number GW 7181-22, which was travelling towards Accra with passengers on board
Preliminary information is that the vehicle had a tyre burst and veered off the road leading to the accident.
The Fire officer said fire personnel received a call at 2:42 pm reporting an accident on the Mankessim-Apam stretch of the Cape Coast-Accra highway.