Four of the patients have died, with three deaths occurring at the Metropolitan Hospital at Bakaano while the other occurred at the Cape Coast Teaching Hospital.
The Metropolitan Director of Health Services, Mr Samuel Sosi said the situation is being managed to curtail the spread.
He noted that cases were being reported at the Metropolitan Hospital, the Cape Coast Teaching Hospital, the University of Cape Coast (UCC) Hospital and the Ewim Government Hospital.
The Director of Health Services at UCC, Dr Kibiru Azeez said in an interview that 30 cases of cholera had been recorded at the hospital since last week.
He indicated that 27 of the cases had been confirmed as cholera and treated. The three other cases whose results came out negative have also been treated and discharged.
He said the cases came from Kotokuraba, others from London Bridge while a few others came from Elmina. Some of the victims were visitors from Accra.
Over the weekend, the metropolitan health directorate in collaboration with the Cape Coast Metropolitan Assembly organised a massive clean up to rid the city of filth.
Mr Sosi said there had been several announcements of the cases to ensure that the people observed proper hygiene to bring the situation under control.
He also indicated that the deaths were due to late arrivals at the hospitals.
Dr Azeez commended the regional health directorate for the prompt support in dealing with the situation.